A description of the use of animals used to ensure the safety of our consumer products and drugs

Enos the space chimp before insertion into the Mercury-Atlas 5 capsule in This rat is being deprived of restful sleep using a single platform "flower pot" technique. The water is within 1 cm of the small flower pot bottom platform where the rat sits.

A description of the use of animals used to ensure the safety of our consumer products and drugs

Agricultural and industrial chemicals

Medical evaluation and preventive medicine for personnel Where appropriate, special precautions for personnel working with nonhuman primates For guidelines on establishing and maintaining an effective safety program, check out Occupational Health and Safety in the Care and Use of Research Animalspublished by the National Research Council.

Animal Facilities and Species Inventory Institutions provide a facility and species inventory as part of their domestic assurance. OLAW uses this information to assess the nature and size of the animal care and use program and evaluate the adequacy of other program components, e. Review and approve animal use protocols, including significant changes to previously approved protocols Institutional definitions of a "significant change" vary.

Be sure you know your institution's policy. Ensure that personnel working with animals are appropriately trained and qualified Find out your institution's policies before you plan your research.

Some are more stringent than others, so a procedure you performed at another institution may not be acceptable at your current workplace. Both institutions must have an OLAW assurance. The foreign subawardee should also follow the instructions in the next section.

The foreign institution must have an assurance.

Types of poison

It states that the institution will comply with your country's laws, regulations, and policies governing the care and use of laboratory animals and follow the International Guiding Principles for Biomedical Research Involving Animals.

A veterinarian with experience in laboratory animal science and medicine, who has direct or delegated authority and responsibility for activities involving animals at the institution.

A description of the use of animals used to ensure the safety of our consumer products and drugs

A practicing scientist experienced in research with animals. A person whose primary concerns are in a nonscientific area, e. A person not affiliated with the institution who represents community interests and who is not a laboratory animal user.

Other IACUC members are usually faculty members and fellow researchers who are familiar with the issues you are facing and can serve as resources to help you prepare the best possible application.

When you send your protocol to your IACUC, it is extremely important that the substantive information is consistent with what you proposed in your grant application. Most IACUCs require investigators to submit information about proposed animal use on an institutional protocol review form.

Before writing your protocol, consult with the attending veterinarian on the latest technologies and procedures that could improve your approach. Also send the veterinarian a draft of your protocol to resolve any issues before it goes to the IACUC. A standard animal protocol includes the following information.


Help IACUC members understand your animal procedures by avoiding technical language only people in your field will understand. Use visual aids, such as flow charts and bullets, to illustrate your points or break up text.

Justification for using animals.

A description of the use of animals used to ensure the safety of our consumer products and drugs

Describe why an animal model is necessary. If you're studying a human health problem, state its cause, existing therapies, and the potential contribution of your experiments to further its understanding. Use lay language, explaining all medical terms and defining acronyms the first time you use them.

Safety Testing - Science, Medicine, and Animals - NCBI Bookshelf

You should generally use the most appropriate and least sentient species capable of providing the data you need. The following is a typical hierarchy of sentient animal species. Non-human primates, such as monkeys, marmosets, and baboons Large animals, such as cats, dogs, and pigs Rabbits Rodents, such as hamsters, rats, and mice Non-mammalian vertebrates, such as poultry, reptiles, and fish Your rationale for using a species may be size or availability; the existence of previous work or laboratory data that validates the use of a certain animal model; or the availability of reagents.

Justification for number of animals. Request the amount of animals you need and explain why. Use the minimum number needed to yield statistically significant results.

Use techniques to minimize pain and distress. These are known as "refinements" to your protocol. List databases you searched and when, citations derived, and the keywords or search strategy.

List other sources, such as journal articles, presentations, and colleagues. Description of animal procedures.Types of poison. In regard to poisoning, chemicals can be divided into three broad groups: agricultural and industrial chemicals, drugs and health care products, and biological poisons—i.e., plant and animal sources.

These three groups, along with a fourth category, radiation, are discussed urbanagricultureinitiative.com://urbanagricultureinitiative.com Over the years, accumulated knowledge of specific products, product classes, and across various product classes led to improved preclinical developments, but NHP use increased rather than decreased, in large part to be more consistent with the practices used for pharmaceuticals (ICH M3).urbanagricultureinitiative.com  · Module I: Introduction to Toxicology and Dose-Response Description This introductory module defines toxicology, briefly summarizes its history, and outlines its relevance to our daily lives, in food, drugs, and consumer products, and its impact in emerging fields such as urbanagricultureinitiative.com The safety of aquatic food products, the integrity of the environment, the safety of target animals, and the safety of persons who administer various compounds are important issues that have an effect on drug use in the aquaculture urbanagricultureinitiative.com://urbanagricultureinitiative.com  · The federal government and many health charities waste precious dollars from taxpayers and well-meaning donors on animal experiments at universities and private laboratories, instead of supporting promising clinical, in vitro, epidemiological, and urbanagricultureinitiative.com At issue here are not just the safe handling and use of our products, but also the transparent communication and transfer of product safety information.

Product stewardship involves both compliance with statutory requirements and voluntary urbanagricultureinitiative.com://urbanagricultureinitiative.com

Domitor for Animal Use - urbanagricultureinitiative.com